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. 2016 Jan 12;7(6):7096–7109. doi: 10.18632/oncotarget.6898

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Copyright: © 2016 Cheng et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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A. YM155 inhibits mRNA expression of survivin. SGC-7901 & MKN-28 cells were treated with YM155 at indicated dose for 24 hours. The mRNA expression of survivin was determined by RT-PCR. B.-D. YM155 induces apoptosis of gastric cancer cells. SGC-7901 cells and AGS cells were treated with YM155 at indicated doses for 24 hours. Apoptosis was determined by FACS analysis. Representative FACS Plots was shown in B. The apoptotic rates are the means ± SD of 3 independent experiments * P < 0.05 compared with the control group.