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. 2016 Jan 12;7(6):7096–7109. doi: 10.18632/oncotarget.6898

Figure 4. YM155 inhibits formation and expansion of gastric cancer spheres.

Figure 4

A. YM155 inhibits sphere formation of gastric cancer cells. SGC-7901 and AGS cells (100 per well) were cultured for 2 weeks in SCM supplement with or without YM155 at indicated doses. The spheres were counted under microscope. The data presented are the means ± SD of 3 independent experiments.* P < 0.05 compared with the control group. B. YM155 inhibits expansion of spheres of gastric cancer cells. SGC-7901 cells were cultured for 1 week in SCM to form sphere (upper panel), and then treated with YM155 at indicated doses for another 1 week. YM155 treatment inhibits growth of spheres. Representative photos were taken at one week after the YM155 treatment (200 ×). C. YM155 inhibited expression of CSC molecules. SGC-7901 cells were treated with YM155 at indicated doses for 24 hours. The protein levels of genes were determined by Western Blot.