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. 2016 Jan 12;7(6):7096–7109. doi: 10.18632/oncotarget.6898

Figure 6. YM155 induces apoptosis and inhibits gastric CSCs in vivo.

Figure 6

A. YM155 treatment decreased protein levels of survivin and CD44. Xenograft tumor tissues (from Figure 5) were extracted and protein concentrations were measured. The levels of protein were determined by Western blot (left panel). The data of the densities presented are means ± SD of 3 mice. B. YM155 treatment inhibits expression of surviving, cleaved caspase-3 and CD44. Tissue sections were subjected to surviving, cleaved caspase-3 and CD44 immunostaining. Representative photos were shown (Original magnification × 400). C.-D. Quantification analysis of survivin and cleaved caspase 3 positive staining cells. Data presented are means ± SD of 7 mice. *p < 0.01, compared to control treatment. E. Quantification analysis of intensities of CD44 positive staining cells. Data presented are means ± SD of five mice. *p < 0.01, compared to control treatment.