Figure 7. Scheme of proposed mechanism for regulation of c-Myc by miRNA on PRIMA-1Met treatment.
miRNA-29a-mediated targeting of c-Myc by PRIMA-1Met may occur as a direct inhibitory effect of the miRNAs. Alternatively, such inhibition can be seen as an indirect effect of the miRNAs which may be mediated by other targets including Mcl-1 or Bcl-2.