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. Author manuscript; available in PMC: 2016 May 19.
Published in final edited form as: Nat Rev Mol Cell Biol. 2012 Mar 7;13(4):225–238. doi: 10.1038/nrm3293

Figure 3. Overview of sirtuins’ role in the regulation of lipid metabolism.

Figure 3

Red arrows indicate activating effects whereas blue bars denote inhibiting functions. Colored symbols show metabolic processes, genes or proteins, which are affected by the nuclear function(s) of SIRT1 or SIRT6. The involvement of certain specific sirtuins in the control of particular metabolic pathway is indicated with white oval.