| SIRT1 |
I |
Nuclear, cytosolic |
Deacetylation |
PGC1α, FOXO1, FOXO3, p53, NOTCH, NF-κB, HIF1α, LXR, FXR, SREBP-1c, and more |
5,30,32,33,39,41,42
|
| SIRT2 |
I |
Cytosolic |
Deacetylation |
Tubulin, PEPCK, FOXO1, PAR-3 |
58–61
|
| SIRT3 |
I |
Mitochondrial |
Deacetylation |
LCAD, HMGCS2, SOD2, GDH, IDH2, OXPHOS complexes, and more |
46–49,51–57
|
| SIRT4 |
II |
Mitochondrial |
ADP-ribosylation |
GDH |
17 |
| SIRT5 |
III |
Mitochondrial |
Deacetylation, demalonylation, desuccinylation |
CPS1 |
21–23
|
| SIRT6 |
IV |
Nuclear |
Deacetylation, ADP-ribosylation |
H3K9, H3K56 |
14,18–20,63
|
| SIRT7 |
IV |
Nucleolus |
Unknown |
unknown |
15,64
|
