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. 2013 Apr-Jun;11(2):190–196. doi: 10.1590/S1679-45082013000200010

Table 3. Pharmaceutical clinical interventions.

Pharmaceutical clinical interventions n (%) Examples
Suspend drug 177 (18.97) Enoxaparin treatment dose in patient with active bleeding; two prescriptions of midazolam in the same order with different dose; omeprazole and ranitidine prescribed in the same order
Replace by safer, more effective and/or cost-effective drug 70 (7.50) Replace omeprazole by ranitidine for stress ulcer. The cost of omeprazole is greater than ranitidine and the efficacy of the prophylaxis is equivalent
Replace by safer, more effective, more cost-effective and/or available presentation/ pharmaceutical form 75 (8.04) Replace sublingual isosorbide dinitrate 5mg 3 times daily by immediate release isosorbide dinitrate 10mg 3 times daily; the sublingual presentation has a lower time of action than another to treat angina
Start drug 46 (4.93) Suggest starting polystyrene sulfonate in a patient with hyperkalemia.
Individualize/correct the posology 470 (50.38) Patient with clearance of creatinine (CrCl) <30mL/min, using enoxaparin. It is recommend to use 50% of the usual dose reported in literature.
Correct preparation and/or administration by nursing 5 (0.54) It is recommend that ceftriaxone and calcium gluconate are not administered together in Y catheter, due the high risk of chemical interaction
Correct order errors (recommendation/prescription) 30 (3.22) Prescription present insulin NPH 30UI in the morning but the order recommendation present insulin NPH 40UI
Provide information/education to healthcare professionals 60 (6.43) Patient was taking clarithromycin and amitriptyline, this association may prolong the QT interval. Give information to the responsible physician to improve monitoring toxicity signals
Total 933