| 13 |
PubMed |
Absence of regulatory T-cell control of TH1 and TH17 cells is responsible for the autoimmune-mediated pathology in chronic graft-versus-host disease. |
Chen X, Vodanovic-Jankovic S, Johnson B, Keller M, Komorowski R, Drobyski WR. |
2007 |
USA |
Experimental |
Treg, Th17 cell and chronic GVHD |
| 14 |
PubMed |
Interferon-gamma regulates idiopathic pneumonia syndrome, a Th17+CD4+ T-cell-mediated graft-versus-host disease. |
Mauermann N, Burian J, von Garnier C, Dirnhofer S, Germano D, Schuett C, Tamm M, Bingisser R, Eriksson U, Hunziker L. |
2008 |
USA |
Experimental |
Th17 cell, CD4 T-cell, idiopathic pneumonia syndrome and GVHD |
| 15 |
PubMed |
Absence of donor Th17 leads to augmented Th1 differentiation and exacerbated acute graft-versus-host disease. |
Yi T, Zhao D, Lin CL, Zhang C, Chen Y, Todorov I, LeBon T, Kandeel F, Forman, S, Zeng D. |
2008 |
USA |
Experimental |
Th17 cell, Th1 cell, acute GVHD |
| 16 |
PubMed |
IL-17 contributes to CD4-mediated graft-versus-host disease. |
Kappel LW, Goldberg GL, King CG, Suh DY, Smith OM, Ligh C, Holland AM, Grubin, J, Mark NM, Liu C, Iwakura Y, Heller G, van den Brink MR. |
2009 |
USA |
Experimental |
IL-17, GVHD |
| 17 |
PubMed |
In vitro-differentiated TH17 cells mediate lethal acute graft-versus-host disease with severe cutaneous and pulmonary pathologic manifestations. |
Carlson MJ, West ML, Coghill JM, Panoskaltsis-Mortari A, Blazar BR, Serody JS. |
2009 |
USA |
Experimental |
Th17 cell, GVHD, cutaneous and pulmonary manifestations. |
| 18 |
PubMed |
Reciprocal differentiation and tissue-specific pathogenesis of Th1, Th2, and Th17 cells in graft-versus-host disease. |
Yi T, Chen Y, Wang L, Du G, Huang D, Zhao D, Johnston H, Young J, Todorov I, Umetsu DT, Chen L, Iwakura Y, Kandeel F, Forman S, Zeng D. |
2009 |
USA |
Experimental |
Th1 cell, Th2 cell and Th17 cell, GVHD, tissue association |
| 19 |
PubMed |
IL-21 blockade reduces graft-versus-host disease mortality by supporting inducible T regulatory cell generation. |
Bucher C, Koch L, Vogtenhuber C, Goren E, Munger M, Panoskaltsis-Mortari A, Sivakumar P, Blazar BR. |
2009 |
USA |
Experimental |
IL-21, GVHD, Treg |
| 20 |
PubMed |
Absence of IL-23p19 in donor allogeneic cells reduces mortality from acute GVHD. |
Thompson JS, Chu Y, Glass J F, Brown SA. |
2010 |
USA |
Experimental |
IL-23p19, mortality, GVHD |
| 21 |
PubMed |
T-helper 17 cells are sufficient but not necessary to induce acute graft-versus-host disease |
Iclozan C, Yu Y, Liu C, Liang Y, Yi T, Anasetti C, Yu XZ |
2010 |
USA |
Experimental |
Th17 cell, GVHD |
| 22 |
PubMed |
STAT3 signaling in CD4+ T-cells is critical for the pathogenesis of chronic sclerodermatous graft-versus-host disease in a murine model. |
Radojcic V, Pletneva MA, Yen HR, Ivcevic S, Panoskaltsis-Mortari A, Gilliam AC, Drake CG, Blazar BR, Luznik L. |
2010 |
USA |
Experimental |
Stat3, Th17 cell, GVHD |
| 23 |
PubMed |
Interleukin-17-producing cells increase among CD4+ lymphocytes before overt manifestation of acute graft-versus-host disease. |
Dlubek D, Turlej E, Sedzimirska M, Lange J, Lange A |
2010 |
Poland |
Clinical |
IL-17, GVHD |
| 24 |
PubMed |
Cutaneous GVHD is associated with the expansion of tissue-localized Th1 and not Th17 cells. |
Broady R, Yu J, Chow V, Tantiworawit A, Kang C, Berg K, Martinka M, Ghoreishi M, Dutz J, Levings MK. |
2010 |
Canada |
Clinical |
Th1 cell, Th17 cell, GVHD, cutaneous |
| 25 |
PubMed |
Development of a T(H)17 immune response during the induction of murine syngeneic graft-versus-host disease. |
Brandon JA, Jennings CD, Kaplan AM, Bryson JS. |
2010 |
USA |
Experimental |
IL-17, CD4+ T-cells, transplantation |
| 26 |
PubMed |
Homing in on acute graft vs. host disease: tissue-specific T-regulatory e Th17 cells. |
Engelhardt BG, Crowe JE |
2010 |
USA |
Review |
Th17, GVHD, Treg |
| 27 |
PubMed |
New perspectives on the biology of acute GVHD. |
Paczesny S, Hanauer D, Sun Y, Reddy P. |
2010 |
USA |
Review |
GVHD, allogeneic, transplantation, bone marrow |
| 28 |
PubMed |
Th17/Treg ratio in human graft-versus-host disease. |
Ratajczak P, Janin A, Peffault de Latour R, Leboeuf C, Desveaux A, Keyvanfar K, Robin M, Clave E, Douay C, Quinquenel A, Pichereau C, Bertheau P, Mary JY, Socié G |
2011 |
France |
Clinical |
Th17 cell, Treg, GVHD, gastrointestinal |
| 29 |
PubMed |
IL-17-producing T-cells contribute to acute GVHD in patients undergoing to non-manipulated blood and marrow transplantation. |
Zhao XY, Xu LL, Lu S Y, Huang XJ. |
2011 |
China |
Clinical |
IL-17, Th17 cells, acute GVHD |
| 30 |
PubMed |
Sequential activation of inflammatory signaling pathways during graft-versus-host disease (GVHD): early role for STAT1 and STAT3. Cell Immunol. 2011;268(1):37-46. |
Ma HH, Ziegler J, Li C, Sepulveda A, Bedeir A, Grandis J, Lentzsch S, Mapara MY. |
2011 |
USA |
Experimental |
Stat1, Stat3, GVHD, inflammation |
| 31 |
PubMed |
Blockade of IL-6-signaling inhibits the pathogenesis of CD4+ T-cell-mediated lethal graft-versus-host reaction against minor histocompatibility antigen. |
Noguchi D, Wakita D, Ohkuri T, Tajima M, Chamoto K, Kitamura H, Nishimura T. |
2011 |
Japan |
Experimental |
IL-6, CD4, GVHD, |
| 32 |
PubMed |
Prevention of GVHD while sparing GVL effect by targeting Th1 and Th17 transcription factor T-bet and RORγt in mice. |
Yu Y, Wang D, Liu C, Kaosaard K, Semple K, Anasetti C, Yu XZ. |
2011 |
USA |
Experimental |
GVL, GVHD, Th17 cell, Tbet |
| 33 |
PubMed |
Th1 and Th17 join forces for acute GVHD |
Teshima T |
2011 |
Japan |
Review |
Th1 cell, Th17 cell, GVHD |
| 34 |
PubMed |
Regulatory T-cells and IL-17-producing cells in graft-versus-host disease. |
Teshima T, Maeda Y, Ozaki K. |
2011 |
Japan |
Review |
Treg, IL-17 cell, GVHD |
| 35 |
PubMed |
Abrogation of donor T-cell IL-21 signaling leads to tissue-specific modulation of immunity and separation of GVHD from GVL. |
Hanash AM, Kappel LW, Yim NL, Nejat RA, Goldberg GL, Smith OM, Rao UK, Dykstra L, Na IK, Holland AM, Dudakov JA, Liu C, Murphy G F, Leonard WJ, Heller G, van den Brink MR. |
2011 |
USA |
Experimental |
IL-21, GVHD, GVL |
| 36 |
PubMed |
Amelioration of acute graft-versus-host disease by adoptive transfer of ex vivo expanded human cord blood CD4+CD25+ FoxP3+ regulatory T-cells is associated with the polarization of Treg/Th17 balance in a mouse model |
Yang J, Fan H, Hao J, Ren Y, Chen L, Li G, Xie R, Yang Y, Qian K, Liu M |
2012 |
China |
Experimental |
Treg, Th17 cell |
| 37 |
PubMed |
Protective role of T-bet and Th1 cytokines in pulmonary graft-versus-host disease and peribronchiolar fibrosis |
Gowdy KM, Nugent JL, Martinu T, Potts E, Snyder LD, Foster WM, Palmer SM. |
2012 |
USA |
Experimental |
Th1 cell, Tbet, GVHD |
| 38 |
PubMed |
Synthetic retinoid Am80 ameliorates chronic graft-versus-host disease by down-regulating Th1 and Th17. |
Nishimori H, Maeda Y, Teshima T, Sugiyama H, Kobayashi K, Yamasuji Y, Kadohisa S, Uryu H, Takeuchi K, Tanaka T, Yoshino T, Iwakura Y, Tanimoto M. |
2012 |
Japan |
Experimental |
Chronic GVHD, Th1 cell, Th17 cell |
| 39 |
PubMed |
Altered balance between Th1 and Th17 cells in circulation is an indicator for the severity of murine acute GVHD. |
Pan B, Zeng L, Cheng H, Song G, Chen C, Zhang Y, Li Z, Xu K. |
2012 |
China |
Experimental |
Th1 cell, Th17 cell, GVHD |
| 40 |
PubMed |
The IL-17 differentiation pathway and its role in transplant outcome. |
Serody JS, Hill GR. |
2012 |
USA |
Review |
Acute, chronic GVHD, Th1 cell, Th17 cell |
