Table 2. Top entities highly ranked by PageRank and Betweenness centrality.

Rank	Disease		Drug		Gene
	PageRank	Betweenness	PageRank	Betweenness	PageRank	Betweenness
1	Tumor	hepatoma	alcohol	gamma-glutamyl	HCC	recombinant human interleukin 2
2	hepatocellular carcinoma	Tumor	cisplatin	Tyrosine	AFP	creatine kinase B
3	Cancer	Cancer	glucose	trastuzumab	p53	G21
4	HCC	autosomal recessive, inherited disorder	oxygen	metallocorrole	CEA	gamma-glutamyl transpeptidase
5	Hepatoma	intrahepatic and extrahepatic cholangiocarcinoma	tyrosine	glutamyl	albumin	ED2
6	Cirrhosis	CRLM and extra hepatic disease	ethanol	[11C]CH3OTf	TACE	CDH2
7	Hepatitis	Thyrotoxicosis	5-FU	3-methylcholanthrene	insulin	thyroid hormone receptor beta
8	colorectal cancer	mitochondrial dysfunction	bilirubin	calcium folinate	alpha-fetoprotein	vascular-endothelial growth factor and fibroblast growth factor receptors
9	liver metastasis	HPV	glutathione	CBD	VEGF	Histone
10	liver cirrhosis	absence of disease progression, fatty liver	amino acid	diethylnitrosamine	IL-6	beta-galactosidase