Table 4. Top 15 entity pairs.

Range	Rank	Disease		Drug		Gene
		PageRank	Betweenness	PageRank	Betweenness	PageRank	Betweenness
> = 1000	1	tumor—hepatocellular carcinoma	tumor—hepatocellular carcinoma	cisplatin—doxorubicin	N/A	HCC—AFP	N/A
> = 1000	2	tumor—HCC	tumor—HCC	bilirubin—aspartate	N/A	HCC—TACE	N/A
> = 1000	3	tumor—liver metastasis	tumor—liver metastasis	cisplatin—5-fluorouracil	N/A	HCC—p53	N/A
> = 1000	4	cirrhosis—hepatitis	tumor—hepatoma	alcohol—ethanol	N/A	HCC—VEGF	N/A
> = 1000	5	hepatocellular carcinoma—liver cirrhosis	cancer—hepatocellular carcinoma	oxygen—superoxide	N/A	HCC—alpha-fetoprotein	N/A
<1000 and > = 100	1	hepatitis—chronic hepatitis	cancer–HCC	cisplatin—platinum	diethylnitrosamine—phenobarbital	AFP—DCP	N/A
<1000 and > = 100	2	cancer—HCC	tumor—metastasis	tyrosine—serine	tyrosine—serine	p53—Bcl-2	N/A
<1000 and > = 100	3	HCC—liver cirrhosis	cancer—liver metastasis	5-FU—folinic acid	3-methylcholanthrene—phenobarbital	p53—p21	N/A
<1000 and > = 100	4	HCC—chronic hepatitis	tumor—liver cirrhosis	cisplatin—adriamycin	tyrosine—sorafenib	insulin—glucagon	N/A
<1000 and > = 100	5	tumor—metastasis	cancer—colorectal cancer	cisplatin—CDDP	gamma-glutamyl—glutamyl	HCC—IFN	N/A
<100	1	cirrhosis—viral hepatitis	hepatoma—hepatitis B	5-FU—uracil	tyrosine—imatinib	TACE—RFA	gamma-glutamyl transpeptidase—alkaline phosphatase
<100	2	hepatoma—hepatitis B	hepatoma—liver cirrhosis	alcohol—aldehyde	tyrosine—threonine	IL-6—IL-10	gamma-glutamyl transpeptidase—HCC
<100	3	liver cirrhosis—liver cancer	hepatoma—liver tumor	glucose—phosphoenolpyruvate	diethylnitrosamine—glutathione	VEGF—CD34	gamma-glutamyl transpeptidase—AST
<100	4	liver metastasis—liver tumor	hepatoma—breast cancer	tyrosine—imatinib	diethylnitrosamine—2-acetylaminofluorene	p53—Bax	histone—HCC
<100	5	cirrhosis—hepatitis C	hepatoma—chronic hepatitis	ethanol—PEIT	diethylnitrosamine—glucose	IL-6—TNF-alpha	histone—HDAC