Table 1.
Brain expression QTL at peak prepulse inhibition-associated markers
| Marker | eQTL P value, region |
Location | Gene | Psychiatric GWAS (human) |
GWAS P value (human) |
|---|---|---|---|---|---|
| rs28029078 (Chr 2) | 1.3E–14 HIP 1.9E–19 STR |
cis | Fam171b | – | – |
| 6.0E–12 HIP 2.2E–16 STR |
cis | Timm10 | – | – | |
| 2.9E–09 HIP 9.2E–07 STR |
trans | Acp2 | – | – | |
| 2.3E–09 HIP 3.5E–11 STR |
trans | Arfgap2 | – | – | |
| 1.2E–09 HIP 8.8E–12 STR |
trans | Rbm45 | – | – | |
| rs37320054 (Chr 7) | 3.7E–08 HIP 1.9E –08 STR |
trans | Prkd3 | Schizophrenia (Ripke et al. 2013) |
6.7 E–09 |
| 7.4E–07 STR | trans | Smarcad1 | Bipolar disorder and schizophrenia (Wang et al. 2010) |
3.7E–06 | |
| 6.9E–08 STR | cis | Htatip2 | – | – | |
| 3.5E–09 STR | trans | Gtf2h1 | – | – |
Hybrid mouse diversity panel eQTL were determined in hippocampus (HIP) and striatum (STR). Genes with start position ±3Mb from eQTL were called cis-eQTL. Genome-wide repository of associations between SNPs and phenotypes (GRASP) was used to determine associations with psychiatric phenotypes.