Fig 11. Prediction: Dose reduction in antibiotic treatment.

Treatment with modified Ampicillin schedule after infection with 5 ⋅ 10⁶ Streptococcus pneumoniae are simulated. Time series of pneumococcal population, neutrophils, IL-6, debris, EU, EA and macrophages in BALF are presented. Therapy starts at 24 h after infection with 0.02 mg/g. Then, dose is reduced to 0.01 mg/g given every 12 hours. Ampicillin treatment is stopped after 48 h (red line) or 60 h (green line). The black dashed line shows the standard treatment with Ampicillin 0.02 mg/g every 12 hours, stopped after 108 hours.