GSC EV proteome predicts patients’ outcome.
A-C. Survival analysis based on the impact of the prognostic index of multiple protein-coding genes from all GSC EVs (A), EVM (B) and EVP (C) based on retrospective data extrapolated from the TCGA.
D. Summarizing cartoon: the heterogeneity of EV cargo contributes to the diverse complexity and enhanced progression of HGG.