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. Author manuscript; available in PMC: 2017 May 1.
Published in final edited form as: Mol Cancer Ther. 2016 Jan 28;15(5):866–876. doi: 10.1158/1535-7163.MCT-15-0729-T

Figure 4. Posaconazole Inhibits SMO Accumulation In Primary Cilia.

Figure 4

(A) Representative immunofluorescent images of NIH-3T3 cells. Stimulation of Hh pathway with SHHN led to accumulation of SMO in primary cilia. Treatment of posaconazole 7.5 μM with SHHN inhibited SMO accumulation in primary cilia. Insets show enlarged views of boxed primary cilia with acetylated tubulin (red) and SMO (green) channels offset for clarity. (B) Tabulation of SMO accumulation in primary cilia. Data represent mean of at least 7 fields +/- S.D. Scale bar represents 10 μm.