Fig. 3. MAO catalytic activity is enhanced by binge ethanol and MAOIs decrease MAO catalytic activity in both control and binge ethanol rats.
MAO enzymatic activity in the frontal cortex of control and binge ethanol rats receiving either no drug or a MAOI were examined using liquid scintillation spectroscopy. (A) MAO-A catalytic activity was significantly increased by binge ethanol. Rasagiline and M30 reduced MAO-A catalytic activity in both control and binge ethanol groups. (B) MAO-B catalytic activity was significantly increased by binge ethanol. All MAOIs (selegiline, rasagiline, M30) significantly decreased MAO-B activity. Data present as mean ± SEM, *p < .05, **p < .01, #p < .001.