Mice harboring U251 tumors were treated according to Schedule D to capture gene expression profile underlying the changes in tumor mass and MVD (n=8 per condition). We registered a significant downregulation of several important proangiogenic factors (A), including Angiopoietins 1 and 2 (ANGPT1, ANGPT2), overall tumor levels of their receptor mouse-Tie-2 (Tek), Neuroligin 1 (NLGN1) as well as Platelet-Derived Growth Factor-B (PDGFB). Interestingly, both mRNA expression (B) and serum protein levels of a human-VEGFA (C) were upregulated slightly in treated animals (n=8,6 for samples treated with vehicle and 1). We selected a panel of prometastatic factors and found that 1 inhibits mRNA expression in all tested transcripts except MMP2 (D). Error bars denote 95% CI.