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. Author manuscript; available in PMC: 2017 Apr 1.
Published in final edited form as: Cancer Res. 2016 Feb 8;76(7):1714–1723. doi: 10.1158/0008-5472.CAN-15-0338

Figure 2.

Figure 2

Summary of somatic mutations and mutation spectrum in GNCA, GCA, and ESCC genomes and non-negative matrix factorization (NMF) analysis of SNV substitution matrix.

Somatic SNV are summarized in Figure 2a–b. The numbers of somatic mutations per million bases in intergenic, intronic, and exonic regions of GCA, GNCA, and ESCC genomes are illustrated with bar graphs. Here somatic mutations include single nucleotide variations and small indels. (a) The graph shows mutations in intergenic, intronic, and exonic regions whereas. (b) The graphs shows mutations of various types of amino-acid changes. SNV substitution patterns are summarized in Figure 2c–d. (c) The graph shows the numbers of somatic mutations for the six types of base substitutions are summarized on the left. We also consider the context of 5 prime base and 3 prime base; there are 96 possible combination (4 times 6 times 4). (d) The heatmap shows the results for the 15 tumors.