Table 1.
Liver tumor formation in Rassf1a and Sav1 deficient mice
| Rassf1a | Sav1 | No. of Mice |
Mean Age (days) |
Median Age (days) |
No of mice with hepatocellular tumors |
Hepatocellular CA |
Hepatocellular CA, mixed* |
Hepatoblastoma | Hepatocellular adenoma |
Hepatocellular adenoma, mixed* |
|---|---|---|---|---|---|---|---|---|---|---|
| wt | +/− | 49 | 591 | 607 | 47 95.90% |
35 71.40% |
14 28.60% |
0% | 32 65.30% |
17 34.70% |
| −/− | +/− | 39 | 583 | 626 | 35 89.70% |
30 77% |
9 23.10% |
1 2.60% |
31 79.50% |
15 38.50% |
| −/− | wt | 45 | 643 | 642 | 19 42% |
4 8.90% |
1 2.20% |
0 0% |
14 31.10% |
2 4.40% |
| wt | wt | 30 | 613 | 659 | 6 20% |
0 0% |
0 0% |
0 0% |
6 20% |
0 0% |
*
The designation mixed tumor refers to tumors which in addition to a hepatocellular component also had a “small cell / oval cell” component. Mean age and median age refer to overall survival of all mice of the respective genotype.