Figure 4. Corticostriatal circuit model implements MeSH rule and experimental validation.

a) Change in movement velocity (au) as a function of number of simulated trials (shaded area indicates standard deviation; N=100) for simulations in which dMSN (blue) or iMSN (red) were stimulated during fastest ~30% of reaches. b) Histogram of the change in the average slope between dMSN (blue) or iMSN (red) activity and movement velocity for simulations with dMSN stimulation. Triangles indicate mean. Circles indicate mean change in weight of corticostriatal synapse (see text for details). c) Mean firing rate during movement (0-505ms after onset) is plotted as a function of peak movement velocity with overlaid linear fit (‘tuning slope’) for 3 of 35 example striatal units. d) Stimulation Response (percent change in baseline firing rate during photostimulation) as a function of the change in the tuning slope (‘ΔSlope’) for unstimulated trials (subthreshold velocity) of sessions in which dMSN were stimulated on the fastest third of movements. Linear fit overlaid (r = 0.47).