Table 5.
Multivariate analyses of drug interactions with gait speed decline ≥ 0.1 m/s stratified by gait speeda
| Variables | Model 1b | Model 2c | Model 3d | |||
|---|---|---|---|---|---|---|
| OR (95% CI) | OR(95% CI) | OR(95% CI) | ||||
| Slow walkers | Fast walkers | Slow walkers | Fast walkers | Slow walkers | Fast walkers | |
| Any DDxI | 1.32 (1.01, 1.73) | 1.29 (0.91, 1.82) | 1.29 (0.98, 1.70) | 1.23 (0.86, 1.74) | 1.24 (0.93, 1.67) | 1.10 (0.76, 1.58) |
| Any DDI | 1.26 (0.98, 1.63) | 1.08 (0.83, 1.41) | 1.27 (0.99, 1.65) | 1.09 (0.84, 1.42) | 1.23 (0.93, 1.63) | 0.97 (0.74, 1.28) |
| Either type of interaction |
1.28 (1.03, 1.58) | 1.15 (0.92, 1.44) | 1.27 (1.02, 1.57) | 1.13 (0.90, 1.42) | 1.23 (0.97, 1.55) | 1.03 (0.81, 1.31) |
| Total number of interactions |
||||||
| 0 | [referent] | [referent] | [referent] | [referent] | [referent] | [referent] |
| 1 | 1.22 (0.94, 1.57) | 1.18 (0.91, 1.51) | 1.21 (0.94, 1.56) | 1.16 (0.90, 1.49) | 1.16 (0.89, 1.52) | 1.09 (0.84, 1.41) |
| ≥2 | 1.43 (1.02, 2.00) | 1.06 (0.67, 1.67) | 1.41 (1.00, 1.99) | 1.04 (0.66, 1.64) | 1.40 (0.96, 2.05) | 0.84 (0.53, 1.34) |
a
Slow versus fast walkers based on a median split at 1.15 m/s.
b
Not adjusted for any covariates.
c
Adjusted for baseline sex, race, education, site and time-varying age.
d
Adjusted for baseline sex, race, education, site, coronary heart disease, diabetes, osteoarthritis, osteoporosis, peripheral arterial disease, pulmonary disease, stroke, depression, and time-varying age, self-rated health, hospitalizations in the past 12 months, total prescription and total over-the-counter medications.
Abbreviations: CI = confidence interval; DDI = drug-drug interaction; DDxI = drug-disease interaction; OR = odds ratio.