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. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: Neuropharmacology. 2016 Jan 6;105:114–123. doi: 10.1016/j.neuropharm.2015.12.026

Figure 2. ACE2 overexpression attenuates anxiety-like behavior, an effect that is reproduced by pharmacological activation of brain ACE2 and is eliminated by blockade of central MasR.

Figure 2

(A–D) Anxiety-like behavior of WT littermates and ACE2 KI mice tested in the elevated plus maze (EPM). (E–H) Anxiety-like behavior of C57BL/6 mice tested in the EPM after icv infusion (0.11 μl/h) of normal saline or DIZE (D1, 1 μg/μl; D10, 10 μg/μl; D100, 100 μg/μl). (I–L), Anxiety-like behavior of WT littermates and ACE2 KI mice tested in the EPM after icv infusion (0.11 μl/h) of A-779 (2 μg/μl). Bars represent mean and SEM. * = P < 0.05 vs. WT or Saline; ** = P < 0.01; $ = P < 0.05 vs. D1; $$ = P < 0.01 vs. D1.