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. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: Neuropharmacology. 2016 Jan 6;105:114–123. doi: 10.1016/j.neuropharm.2015.12.026

Figure 5. ACE2 overexpression increases basal sIPSCs frequency in BLA pyramidal neurons by acting on MasRs.

Figure 5

(A) Representative recording of sIPSCs from pyramidal neurons in BLA of a WT control (top) and ACE2 KI mouse (bottom). (B) Representative recording of sIPSCs from principal neurons in the BLA showing sensitivity to picrotoxin (PTX), a GABAA receptor antagonist. (C) Summary data for sIPSCs frequency recorded from animals without A-779 infusion. (D) Summary data for sIPSCs frequency recorded from animals that received chronic brain infusion of A-779 (2μg/μl) for 7 days. Bars represent mean and SEM. * = P < 0.05