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. Author manuscript; available in PMC: 2017 May 1.
Published in final edited form as: Cancer Res. 2016 Mar 17;76(9):2513–2524. doi: 10.1158/0008-5472.CAN-15-1325

Fig 4. Transendothelial migration is mediated by α3β1 and α6β1 integrins via interactions with laminin.

Fig 4

(A) Percentage transendothelial migration in microvascular network devices at 6 hours when tumor cells are treated with function-blocking antibodies for various α and β subunits (n=3 experiments, 3 devices per condition, *p<0.05, **p<0.01, ***p<0.001, bars represent mean +/− SEM). (B) Western blot analysis of alpha 3 and alpha 6-integrin individual knockdowns and co-knockdowns in MDA-MB-231 via siRNA. (C) Kinetics of TEM in microvascular networks following the same regions at 0, 6, 12 and 24 hr after tumor cell seeding.