Table 1.
Parameters for sensitivity analyses
| Parameter | Mean | Plausible range | Distribution | Source |
|---|---|---|---|---|
| Testing operating characteristics | ||||
| Papanicolaou smear, sensitivity | 0.84 | 0.69 – 0.88 | Beta | (11) |
| Papanicolaou smear, specificity | 0.88 | 0.77 – 0.93 | Beta | (11) |
| Colposcopy, probability of normal result given normal histology | 0.57 | 0.51 – 0.62 | Beta | (17) |
| Colposcopy, probability of LSIL result given CIN-1 histology | 0.48 | 0.40 – 0.55 | Beta | (17) |
| Colposcopy, probability of HSIL result given CIN-2 histology | 0.71 | 0.65 – 0.77 | Beta | (17) |
| Treatment parameters | ||||
| Treatment adherence after a biopsy positive for HSIL | 50% | 30% – 90% | Beta | (20, 2) |
| Loss of quality of life from LEEP treatment (QALY) | 0.01 | 0.00 – 0.04 | Beta | Estimate |
| Costs (2012 US$) | ||||
| Colposcopy | $292 | $206 – $371 | Log-normal | (8) |
| Biopsy | $322 | $227 – $408 | Log-normal | (8) |
| Papanicolaou smear | $88 | $44 – $252 | Gamma | (11) |
| Treating HSIL | $4,996 | $2,268 – $6,887 | Log-normal | (10) |
| Treating cancer stage I | $28,914 | $15,467 – $35,962 | Log-normal | (10) |
| Treating cancer stage II | $44,357 | $19,228 – $47,667 | Log-normal | (10) |
| Treating cancer stage III | $44,357 | $19,228 – $47,667 | Log-normal | (10) |
| Treating cancer stage IV | $66,006 | $20,762 – $76,213 | Log-normal | (10) |
LSIL: low-grade squamous intraepithelial lesions, HSIL: high-grade squamous intraepithelial lesions, CIN: cervical intraepithelial neoplasia, LEEP: loop electrosurgical excision procedure, QALY: quality-adjusted life-year.