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. Author manuscript; available in PMC: 2017 Apr 15.
Published in final edited form as: Cancer Res. 2016 Feb 18;76(8):2394–2405. doi: 10.1158/0008-5472.CAN-15-1548

Figure 7. Differences in IL-18 expression between tumor and non-tumor tissue strongly correlate with prognosis.

Figure 7

(A) Representative intratumoral and peritumoral staining (400X magnification) for IL-18 from three patients. Sample 1: middle intratumoral density, low peritumoral density, low difference in staining density; Sample 2: low intratumoral density, low peritumoral density, middle difference in staining density; Sample 3: high intratumoral density, high peritumoral density, high difference in staining density. (B) Kaplan-Meier curves for overall (top) and disease-free survival (bottom) of the 138 patients stratified into the highest, middle, or lowest third of patients based on differences in IL-18 staining density (Supplementary Table S4, Supplementary Fig. S18). Statistics: (B) Log-rank Mantel-Cox tests, n=46 per group.