Table 1.
Spontaneous primary malignant tumor types observed in Bap1-mutant mice a
| Tumor types | Bap1−/− | Bap1+/L | Bap1+/W | Total tumorsb |
|---|---|---|---|---|
| Ovarian SCST | 8 | 14 | 16 | 38 |
| Lung carcinoma | 4 | 1 | 2 | 7 |
| Mammarycarcinoma | 3 | 1 | 2 | 6 |
| Spindle cell tumor | 2 | 3 | 1 | 6 |
| MM | 1 | 0 | 1 | 2 |
| Lymphoma | 0 | 2 | 0 | 2 |
| Colon carcinoma | 1 | 0 | 0 | 1 |
| Harderian gland carcinoma |
0 | 1 | 0 | 1 |
| Uterine adenocarcinoma |
0 | 1 | 0 | 1 |
| Islet cell tumor | 0 | 0 | 1 | 1 |
a
Among 43 wild-type (Bap1+/+) littermates (not summarized here), 2 had mammarycarcinoma and 2 others had lung carcinoma.
b
Overall number of tumors (66) is greater than the number of mice with cancer (55), because 11 Bap1-mutant mice had two independent primary tumors involving different organs. Additionally, 12 ovarian SCSTs were bilateral.