Table 2.
Hazard ratios (95% CI) for the incidence of total cancer and cancer types by quartiles of B2M; ARIC, 1990–2006.
| Cancer | No. of cases |
Quartiles of B2M (mg/L) | ||||
|---|---|---|---|---|---|---|
| ≤1.66 | 1.67–1.88 | 1.89–2.15 | ≥2.16 | P-trend | ||
| Total cancer | 2,436 | 512 | 583 | 659 | 682 | |
| Person-years | 162,617 | 42,356 | 42,688 | 40,069 | 37,503 | |
| Incidence ratesa | 14.98 | 12.09 | 13.66 | 16.45 | 18.18 | |
| Model 1b | 1 (reference) | 1.01 (0.89–1.14) | 1.14 (1.02–1.29) | 1.20 (1.07–1.36) | 0.0003 | |
| Model 2c | 1 (reference) | 1.02 (0.89–1.17) | 1.20 (1.05–1.38) | 1.25 (1.06–1.47) | 0.002 | |
| Colorectal cancer | 255 | 44 | 64 | 77 | 70 | |
| Person-years | 162,617 | 42,356 | 42,688 | 40,069 | 37,503 | |
| Incidence rates | 1.57 | 1.04 | 1.50 | 1.92 | 1.87 | |
| Model 1 | 1 (reference) | 1.35 (0.91–1.99) | 1.66 (1.13–2.43) | 1.55 (1.04–2.30) | 0.02 | |
| Model 2 | 1 (reference) | 1.37 (0.89–2.09) | 1.93 (1.25–2.99) | 2.21 (1.32–3.70) | 0.001 | |
| Lung cancer | 298 | 59 | 72 | 66 | 101 | |
| Person-years | 162,617 | 42,356 | 42,688 | 40,069 | 37,503 | |
| Incidence rates | 1.83 | 1.39 | 1.69 | 1.65 | 2.69 | |
| Model 1 | 1 (reference) | 0.99 (0.70–1.40) | 0.88 (0.61–1.26) | 1.31 (0.93–1.84) | 0.12 | |
| Model 2 | 1 (reference) | 1.09 (0.74–1.61) | 0.98 (0.64–1.50) | 1.64 (1.03–2.61) | 0.06 | |
| Breast cancer (women only) | 424 | 103 | 91 | 103 | 127 | |
| Person-years | 92,554 | 25,434 | 23,206 | 22,114 | 21,801 | |
| Incidence rates | 4.58 | 4.05 | 3.92 | 4.66 | 5.83 | |
| Model 1 | 1 (reference) | 0.88 (0.66–1.17) | 0.99 (0.75–1.31) | 1.19 (0.90–1.56) | 0.14 | |
| Model 2*d | 1 (reference) | 0.84 (0.58–1.23) | 1.13 (0.78–1.64) | 1.01 (0.64–1.59) | 0.62 | |
| Prostate cancer | 524 | 119 | 153 | 149 | 103 | |
| Person-years | 70,062 | 16,922 | 19,482 | 17,955 | 15,703 | |
| Incidence rates | 7.48 | 7.03 | 7.85 | 8.30 | 6.56 | |
| Model 1 | 1 (reference) | 1.12 (0.87–1.42) | 1.15 (0.90–1.48) | 0.82 (0.62–1.08) | 0.21 | |
| Model 2 | 1 (reference) | 1.14 (0.88–1.48) | 1.20 (0.89–1.62) | 0.95 (0.66–1.36) | 0.98 | |
| Hematological cancers | 176 | 35 | 38 | 43 | 60 | |
| Person-years | 162,617 | 42,356 | 42,688 | 40,069 | 37,503 | |
| Incidence rates | 1.08 | 0.83 | 0.89 | 1.07 | 1.60 | |
| Model 1 | 1 (reference) | 0.92 (0.58–1.47) | 1.02 (0.65–1.62) | 1.42 (0.92–2.21) | 0.07 | |
| Model 2 | 1 (reference) | 1.06 (0.62–1.79) | 1.17 (0.67–2.00) | 1.50 (0.80–2.81) | 0.18 | |
a
Per 1,000 person-years
b
Model 1 – adjusted for age, sex, race-study center.
c
Model 2 – all variables in Model 1 + education, BMI, smoking status and pack-years of smoking, use of aspirin, hormone replacement therapy (in women) and eGFR.
d
Model 2*– all variables in Model 2 + menopausal status, age at menarche, and number of live births.