Skip to main content
. Author manuscript; available in PMC: 2017 Apr 1.
Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2016 Feb 5;25(4):657–664. doi: 10.1158/1055-9965.EPI-15-0849

Table 2.

Hazard ratios (95% CI) for the incidence of total cancer and cancer types by quartiles of B2M; ARIC, 1990–2006.

Cancer No. of

cases
Quartiles of B2M (mg/L)

≤1.66 1.67–1.88 1.89–2.15 ≥2.16 P-trend
Total cancer 2,436 512 583 659 682
  Person-years 162,617 42,356 42,688 40,069 37,503
  Incidence ratesa 14.98 12.09 13.66 16.45 18.18
  Model 1b 1 (reference) 1.01 (0.89–1.14) 1.14 (1.02–1.29) 1.20 (1.07–1.36) 0.0003
  Model 2c 1 (reference) 1.02 (0.89–1.17) 1.20 (1.05–1.38) 1.25 (1.06–1.47) 0.002

Colorectal cancer 255 44 64 77 70
  Person-years 162,617 42,356 42,688 40,069 37,503
  Incidence rates 1.57 1.04 1.50 1.92 1.87
  Model 1 1 (reference) 1.35 (0.91–1.99) 1.66 (1.13–2.43) 1.55 (1.04–2.30) 0.02
  Model 2 1 (reference) 1.37 (0.89–2.09) 1.93 (1.25–2.99) 2.21 (1.32–3.70) 0.001

Lung cancer 298 59 72 66 101
  Person-years 162,617 42,356 42,688 40,069 37,503
  Incidence rates 1.83 1.39 1.69 1.65 2.69
  Model 1 1 (reference) 0.99 (0.70–1.40) 0.88 (0.61–1.26) 1.31 (0.93–1.84) 0.12
  Model 2 1 (reference) 1.09 (0.74–1.61) 0.98 (0.64–1.50) 1.64 (1.03–2.61) 0.06

Breast cancer (women only) 424 103 91 103 127
  Person-years 92,554 25,434 23,206 22,114 21,801
  Incidence rates 4.58 4.05 3.92 4.66 5.83
  Model 1 1 (reference) 0.88 (0.66–1.17) 0.99 (0.75–1.31) 1.19 (0.90–1.56) 0.14
  Model 2*d 1 (reference) 0.84 (0.58–1.23) 1.13 (0.78–1.64) 1.01 (0.64–1.59) 0.62

Prostate cancer 524 119 153 149 103
  Person-years 70,062 16,922 19,482 17,955 15,703
  Incidence rates 7.48 7.03 7.85 8.30 6.56
  Model 1 1 (reference) 1.12 (0.87–1.42) 1.15 (0.90–1.48) 0.82 (0.62–1.08) 0.21
  Model 2 1 (reference) 1.14 (0.88–1.48) 1.20 (0.89–1.62) 0.95 (0.66–1.36) 0.98

Hematological cancers 176 35 38 43 60
  Person-years 162,617 42,356 42,688 40,069 37,503
  Incidence rates 1.08 0.83 0.89 1.07 1.60
  Model 1 1 (reference) 0.92 (0.58–1.47) 1.02 (0.65–1.62) 1.42 (0.92–2.21) 0.07
  Model 2 1 (reference) 1.06 (0.62–1.79) 1.17 (0.67–2.00) 1.50 (0.80–2.81) 0.18
a

Per 1,000 person-years

b

Model 1 – adjusted for age, sex, race-study center.

c

Model 2 – all variables in Model 1 + education, BMI, smoking status and pack-years of smoking, use of aspirin, hormone replacement therapy (in women) and eGFR.

d

Model 2*– all variables in Model 2 + menopausal status, age at menarche, and number of live births.