. Author manuscript; available in PMC: 2017 Apr 1.

Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2016 Feb 5;25(4):657–664. doi: 10.1158/1055-9965.EPI-15-0849

Table 4.

Hazard ratios (95% CIs) for colorectal cancer incidence by quartiles of biomarker (hs-CRP or B2M) or inflammatory score; ARIC, 1990–2006.

Biomarker	Quartile 1	Quartile 2	Quartile 3	Quartile 4	p-value
B2M (mg/L)	≤1.66	1.67–1.88	1.89–2.15	≥2.16
Number of cases/participants	44/3,063	64/3,140	77/3,046	70/3,051
HR(95% CI) ^a	1 (reference)	1.37 (0.89–2.09)	1.93 (1.25–2.99)	2.21 (1.32–3.70)	0.001

hs-CRP (mg/L)	≤1.07	1.07–2.26	2.27–4.87	≥4.88
Number of cases/participants	42/3,069	59/3,091	76/3,069	78/3,066
HR (95% CI)	1 (reference)	1.36 (0.89–2.09)	1.84 (1.21–2.81)	2.17 (1.39–3.37)	0.0002

Combined Score 1^b	0–1	2–3	4–5	6
Number of cases/participants	44/2,813	82/4,621	97/3,660	32/1,201
HR (95% CI)	1 (reference)	1.19 (0.75–1.67)	1.84 (1.20–2.82)	2.49 (1.42–4.38)	0.0002

Multivariable model (Model 2, Table 2) – adjusted for age, sex, race, study center, education, BMI, smoking status and pack-years of smoking, use of aspirin, hormone replacement therapy (in women) and eGFR.

Sum of hs-CRP and B2M (categorized in quartiles that ranged from to 0 to 3)