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. Author manuscript; available in PMC: 2017 Apr 15.
Published in final edited form as: Cancer Res. 2016 Feb 9;76(8):2177–2185. doi: 10.1158/0008-5472.CAN-15-3139

Figure 3.

Figure 3

CT-RCC HERV-E envelope derived peptides stimulate peptide specific CD8+ T cells that recognize HERV-E expressing ccRCC cells. Flow cytometry data are shown for CTL bulk cultures stimulated two times with the HERV-E-env peptides: A, CR1, B, SU1, and C, TM1. Axis X, numeration of healthy donors. Axis γ, the percentage of IFNγ positive CD8+ T cells following pulsing with control peptide MART-1 (green), pulsing with corresponding HERV-E env-derived peptide (blue), or after co-culturing with HERV-E+/HLA-A*0201- negative ccRCC line (grey), HLA-A*0201+/HERV-E-negative ccRCC line (black), and HLA-A*0201+/HERV-E+ ccRCC line (red). Yellow bars show the percentage of IFNγ positive CD8+ T cells alone.