Table 1.
Personal history of psoriasis and risk of first primary cancer (other than skin keratinocyte carcinoma) (1996-2012) a
| No psoriasis (935,227 person- years) |
Psoriasis (22,132 person-years) |
Age-adjusted HR (95% CI) |
Multivariable- adjusted HR (95% CI)b |
|
|---|---|---|---|---|
| Total cancer | 8139 | 209 | 1.06 (0.92-1.21) | 1.02 (0.89-1.17) |
| Breast cancerc | 4034 | 86 | 0.91 (0.73-1.12) | 0.89 (0.71-1.10) |
| Colorectal cancer | 697 | 20 | 1.19 (0.76-1.86) | 1.11 (0.71-1.73) |
| Non-Hodgkin lymphoma | 527 | 13 | 1.01 (0.58-1.75) | 1.03 (0.59-1.78) |
| Endometrial cancer | 515 | 7 | 0.60 (0.28-1.26) | 0.54 (0.26-1.15) |
| Lung cancer | 429 | 14 | 1.23 (0.72-2.09) | 1.05 (0.61-1.79) |
| Melanomad | 380 | 18 | 2.00 (1.25-3.21) | 1.95 (1.21-3.13) |
| Bladder cancer | 232 | 7 | 1.20 (0.57-2.55) | 1.10 (0.52-2.35) |
| Ovarian Cancer | 194 | 6 | 1.25 (0.55-2.81) | 1.28 (0.56-2.88) |
| Thyroid cancer | 153 | 5 | 1.37 (0.56-3.33) | 1.36 (0.56-3.32) |
| Kidney cancere | 137 | 9 | 2.74 (1.40-5.39) | 2.50 (1.27-4.92) |
| Other Cancersf | 841 | 24 | 1.03 (0.69-1.54) | 0.97 (0.65-1.46) |
CI, confidence interval; HR, Hazard Ratio
Self-reported psoriasis cases that refused the diagnosis were excluded.
Adjusted for age, BMI (<21.0, 21.0-22.9, 23.0-24.9, 25.0-26.9, 27.0-29.9, 30.0-32.9, 33.0-34.9, 35.0-39.9, or ≥40.0 kg/m2), alcohol consumption (none, 0.1-4.9, 5.0-9.9, or ≥10 g/d), physical activity (<3.0, 3.0-8.9, 9.0-17.9, 18.0-26.9, or ≥27.0 metabolic equivalent hours/wk), physical examination (yes or no), multi-vitamin use (yes or no), smoking status (never, past, current smokers with 1-14, 15-24, or ≥25 cigarettes/d), and family history of cancer (yes or no) (except for the analysis of melanoma and breast cancer).
Additionally adjusted for oral contraceptive use (never, past, or current), menopausal status and PMH use (pre-menopause, post-menopause without PMH use, post-menopause with PMH use), personal history of benign breast disease (yes or no), family history of breast cancer (yes or no), age at first birth and parity (nulliparous, age at first birth<25 and parity 1-2, age 25-29 and parity 1-2, age ≥30 and parity 1-2, age <25 and parity ≥3, or age 25-29 and parity ≥3, or age ≥30 and parity ≥3), age at menarche (≤12, 13, or ≥14), height (< 1.60, 1.60-1.64, 1.65-1.70, or ≥1.70 m) and BMI at age 18 (<20, 20-22.4, 22.5-24.9, 25-29.9, or ≥30 kg/m2).
Additionally adjusted for natural hair color (black, dark brown, light brown, blonde, or red), childhood tendency to sunburn (practically none, some redness only, burn, painful burn or burn with blisters), childhood tendency to tanning (practically none, little tan, average tan, or deep tan), number of teenage sunburns (none, 1-2, 3-5, 6-9, or ≥10), family history of melanoma (yes or no), mole count (none, 1-2, 3-4, 5-9, or ≥10), sun exposures at high school, age 25 to 35, 35 to 59, and 60 or older (≤1, 2-5, 6-10, or ≥11 hours/wk for each), and UV index at birth, age 15, and age 30 years (≤5, 6, or ≥7 for each).
Additionally adjusted for history of use of NSAIDs (never, 1-3, 4-6, or >6 years), history of hypertension (yes or no), diabetes (yes or no), and parity (nulliparous, 1-2, or ≥3).
Other individual cancers each with cases less than 100.