Table 2.
Personal history of PST confirmed psoriasis and psoriasis severity and risk of melanoma and kidney cancer as the first primary cancer (1996-2012) a
| Person-years | Number of cases | Age-adjusted HR (95% CI) |
Multivariable- adjusted HR (95% CI)b |
|
|---|---|---|---|---|
| Analysis of melanoma c | ||||
| Ref: No psoriasis | 930,950 | 378 | 1.00 | 1.00 |
| Psoriasis | 15,278 | 14 | 2.30 (1.35-3.92) | 2.21 (1.29-3.77) |
| Categorized by psoriasis severity | ||||
| <1 palm area | 9,730 | 8 | 1.94 (0.92-4.11) | 1.84 (0.87-3.90) |
| ≥1 palm area | 5,548 | 6 | 2.69 (1.20-6.03) | 2.65 (1.18-5.97) |
| P for trend by palm area (continuous) | 0.002 | 0.003 | ||
|
| ||||
| Analysis of kidney cancer d | ||||
| Ref: No psoriasis | 930,950 | 136 | 1.00 | 1.00 |
| Psoriasis | 15,278 | 7 | 3.15 (1.47-6.73) | 2.88 (1.34-6.17) |
| Categorized by psoriasis severity | ||||
| <1 palm area | 9,730 | 2 | 1.39 (0.34-5.61) | 1.27 (0.31-5.12) |
| ≥1 palm area | 5,548 | 5 | 6.37 (2.60-15.57) | 5.86 (2.39-14.39) |
| P for trend by palm area (continuous) | 0.0002 | 0.0004 | ||
CI, confidence interval; HR, Hazard Ratio
Self-reported psoriasis cases that refused the diagnosis or that did not get into the validation study were excluded.
Adjusted for age, BMI (<21.0, 21.0-22.9, 23.0-24.9, 25.0-26.9, 27.0-29.9, 30.0-32.9, 33.0-34.9, 35.0-39.9, or ≥40.0 kg/m2), alcohol consumption (none, 0.1-4.9, 5.0-9.9, or ≥10 g/d), physical activity (<3.0, 3.0-8.9, 9.0-17.9, 18.0-26.9, or ≥27.0 metabolic equivalent hours/wk), physical examination (yes or no), multi-vitamin use (yes or no), smoking status (never, past, current smokers with 1-14, 15-24, or ≥25 cigarettes/d),.
Additionally adjusted for natural hair color (black, dark brown, light brown, blonde, or red), childhood tendency to sunburn (practically none, some redness only, burn, painful burn or burn with blisters), childhood tendency to tanning (practically none, little tan, average tan, or deep tan), number of teenage sunburns (none, 1-2, 3-5, 6-9, or ≥10), family history of melanoma (yes or no), mole count (none, 1-2, 3-4, 5-9, or ≥10), sun exposures at high school, age 25 to 35, 35 to 59, and 60 or older (≤1, 2-5, 6-10, or ≥11 hours/wk for each), and UV index at birth, age 15, and age 30 years (≤5, 6, or ≥7 for each).
Additionally adjusted for history of use of NSAIDs (never, 1-3, 4-6, or >6 years), history of hypertension (yes or no), diabetes (yes or no), and parity (nulliparous, 1-2, or ≥3).