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. 2015 Dec 3;65(2):135–146. doi: 10.1538/expanim.15-0082

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©2016 Japanese Association for Laboratory Animal Science

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License.

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Fig. 1. — Cell cycle progression during mouse liver regeneration. A, Percentage of hepatocytes and biliary epithelial cells with PCNA-positive nuclei. B, Percentage of hepatocytes and biliary epithelial cells with Ki67-positive nuclei. C, Percentage of hepatocytes and biliary epithelial cells with topoisomerase IIα-positive nuclei. D, Percentage of hepatocytes and biliary epithelial cells with P.H3-positive nuclei. E, Mitotic index of hepatocytes and biliary epithelial cells. Over 1,000 cells per liver were counted. Data are shown as mean +/− standard deviation. While most hepatocytes semi-synchronously enter the S or M phase at PH48 and PH72, biliary epithelial cells have delayed and slow cell cycle progression (A-E). The number in parentheses is the number of animals examined.