Fig. 2.

Simulated profile for plasma 1-MT concentrations after five repetitive s.c. administrations once a day (dashed line) deduced from the single dose experiment and plasma 1-MT concentrations after five s.c. administrations at 0, 24, 48, 72, and 96 h. Samples were taken immediately prior to the first administration of 1-MT and 24 h (time points 24, 48, 72, and 96 h) or 12 h (time points 84 and 108 h) after the preceding administration of 1-MT. 1-MT concentrations are presented as the least square means ± the standard error (n=12 for time points 0, 24, 48, 72, and 84 h; n=6 for time points 96 and 108 h). Significant differences (P < 0.05) between time points are shown by different letters. At 0 h, 1-MT was not detectable in plasma.