Table 1. Pharmacokinetic parameters of 1-MT after a single s.c. administration of 1 g 1-MT to pigs.
Parameters | Units | 1-MT |
---|---|---|
Cmax | µM | 29.07 ± 7.97 |
Tmax | h | 12 ± 0 |
k | h-1 | 0.065 ± 0.011 |
T1/2 | h | 10.93 ± 2.03 |
AUC0→t | µM h | 959.9 ± 345.8 |
Cmax, maximum concentration in pigs plasma; Tmax, time to reach maximum plasma concentration; k, first-order kinetic rate constant; T1/2, half-life; AUC0→t, area under the concentration-time curve from time zero to 168 h. means ± standard deviation, n= 3.