Table 4.
Pharmacology of T-type calcium channel isotypes.
| Agent (type/class) | CaV3.1 | CaV3.2 | CaV3.3 | CaV1.x | Reference |
|---|---|---|---|---|---|
| IC50 (μM) | |||||
| Nickel (inorganic ion) | 250–470 | 5.4–13.0 | 180–216 | >200 | (53, 55, 83–86) |
| Mibefradil (antihypertensive) | 0.12–1.20 | 1.0–1.4 | 1.5 | >12 | (51, 53, 84, 87–90) |
| Phenytoin (anticonvulsant) | 75–140 | 8–192 | ? | >360 | (83, 91) |
| Propofol (anesthetic) | 20 | 27 | ? | (91) | |
| Pentobarbital (barbiturate) | 310 | 345 | ? | >600 | (91) |
| Kurtoxin (scorpion toxin) | 0.015 | 0.061 | ? | >10 | (92) |
| Pimozide (neuroleptic) | 0.035 | 0.054 | 0.030 | (93) | |
| Flunarizine (neuroleptic) | 0.53 (KD) | 3.55 (KD) | 0.84 (KD) | (93) | |
| Anandamide (cannabinoid) | 4.15 | 0.33 | 1.10 | (94) | |
| Amiloride (diuretics) | 156–167 | (53, 86) | |||
| Curcumin (condiment) | 20 | (95) | |||
| TTA-P2 (antinociceptive) | 0.35 | >3 | (75) | ||
Bold indicates the channel isoform with the highest sensitivity to the most discriminant drugs.