Fig. 1.

Relative frequency of antibodies against citrullinated and carbamylated sequences of vimentin, anti-CCP2 and RF in patients with early and established RA. RA rheumatoid arthritis, RF rheumatoid factor, CCP2 cyclic citrullinated peptides of second generation, MCV mutated citrullinated vimentin, carbVIM carbamylated vimentin, carbMCV carbamylated mutated citrullinated vimentin, CCP VIM cyclic citrullinated peptides of vimentin, Ig immunoglobulin. Cutoff value of anti-CCP2 was 30 U/mL according to manufacturer’s instruction and for others assay was 20 U/mL