Table 3.
Enriched pathways, functions and activators in the differentially expressed gene lists from male and female rats exposed to 2 mg/kg bw/day furan
| Categories | Male | Female | ||
|---|---|---|---|---|
| Increase | Decrease | Increase | Decrease | |
| Biological functions | 18 (liver injury and inflammation, cell death) | 56 (lipid metabolism, hormone oxidation) | 0 | 0 |
| Toxicological functions | 4 (liver injury and inflammation, cell death) | 2 (liver hemorrhaging) | 0 | 0 |
| Upstream activators | 27 | 25 | 5 (2*) | 6 (1*) |
Cut off vale: activation Z score ≥2 or ≤−2
* Number of elements common with male