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. Author manuscript; available in PMC: 2016 May 20.
Published in final edited form as: J Neural Eng. 2014 Jun 3;11(4):046002. doi: 10.1088/1741-2560/11/4/046002

Figure 3.

Figure 3

Co-presentation of topography and electrical stimulation significantly increase neurite outgrowth. (A) Total neurite outgrowth is enhanced by electrical stimulation alone on PLLA films. Neurite outgrowth is greater on the aligned electrospun PLLA fibers (topographical cues), and the co-presentation of both cues (electrical stimulation and the fibers) serves to further support greater outgrowth. A similar trend is seen in longest neurite length (B). Topographical cues but not electrical stimulation decreases the complexity of neuronal morphology. Both number of branch points (C) and number of primary neurites (D) are significantly reduced on aligned fibers. *= p<0.05 to flat films; #= p<0.05 to flat film and respective controls, n=3.