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. 2016 May 20;6:26608. doi: 10.1038/srep26608

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(a–d) Down-regulated Wnt/β-catenin activity in the VDA (brackets) caused by cyp2aa9MO was rescued by PGE2 as shown by WISH of GFP in the Tg(TOP:dGFP) Wnt-reporter line at 36 hpf. (e) Quantifications of total TOP-positive cells in the major trunk vessels (n = 6, mean ± SD). (f–i) Defective HSC formation in the cyp2aa9 morphants was rescued by PGE2 as shown by cmyb expression. (j–m) Decrease in the number of HSCs in the cyp2aa9 morphants was rescued by PGE2 as shown by the cmyb:GFP transgene. Scale bar, 50 μm. (n) Quantifications of the cmyb:GFP-positive cells in the AGM (n = 8, mean ± SD). *p < 0.05, ***p < 0.001, Student’s t-test. All the views of embryos are lateral, anterior left, dorsal top.