Figure 2. Compounds 31 and 132 stimulate GABA currents mediated by α1β₂γ₂ receptors in a concentration-dependent manner.

α₁β₂γ₂ receptors were expressed in Xenopus oocytes and electrophysiological experiments were performed. Original current traces of an experiment with compound 31 (a) and with compound 132 (b). Numbers indicate applied concentrations of the respective compounds. (c) Concentration dependence of the positive allosteric modulation by compound 31 (closed circles) and compound 132 (closed squares) in oocytes expressing α₁β₂γ₂ receptors. Mean data ± SD for both compounds is shown, n = 3.