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. 2016 May 20;6:26291. doi: 10.1038/srep26291

Figure 6. Loss of Nrf2 prevents vascular cell apoptosis and promotes neointimal formation after the vascular injury.

Figure 6

(a) TUNEL staining and its phase-contrast images of femoral arteries obtained from WT and Nrf2−/− mice at 14 days after injury. (b) Quantitative morphometric analysis of TUNEL-positive cells and vessel remodeling in WT and Nrf2−/− mice. I/M ratio indicates intimal area to medial area ratio. Data are expressed as mean ± SEM of three different sections from each of 10 (WT) or nine (Nrf2−/−) vessels. (c) Hematoxylin & Eosin staining of femoral arteries obtained from the WT and Nrf2−/− mice at 28 days after injury. Arrowheads indicate internal elastic lamina. I, intimal layer. The number of neointimal cells was determined by counting the nucleus. Data are expressed as mean ± SEM of sections from each of five vessels. *P < 0.05 vs. WT mice.