Table 2. Potential confounding variables for the quetiapine-induced DM in FAERS.
| Group | DM without quetiapine (%) | DM with quetiapine (%) | Odds ratio (95% CI) |
|---|---|---|---|
| Limited by an adverse event name | |||
| Diabetes mellitus | 20092/4482388 (0.45) | 7668/65453 (11.72) | 29.47 (28.67–30.30) |
| Diabetic ketoacidosis | 2897/4482388 (0.06) | 1258/65453 (1.92) | 30.30 (28.35–32.39) |
| Diabetic coma | 885/4482388 (0.02) | 876/65453 (1.34) | 68.69 (62.55–75.44) |
| Stratified by age | |||
| <40 years | 3622/657664 (0.55) | 2229/16317 (13.66) | 28.57 (27.03–30.20) |
| 40–49 years | 3982/391629 (1.02) | 2813/11828 (23.78) | 30.38 (28.82–32.02) |
| 50–59 years | 5929/547124 (1.08) | 1690/10574 (15.98) | 17.36 (16.39–18.40) |
| 60–69 years | 5170/536481 (0.96) | 409/4932 (8.29) | 9.29 (8.37–10.32) |
| ≥70 years | 4100/616472 (0.67) | 175/5067 (3.45) | 5.34 (4.58–6.23) |
| Stratified by gender | |||
| Male | 14129/1572620 (0.90) | 4512/24882 (18.13) | 24.43 (23.56–25.33) |
| Female | 18996/2537316 (0.75) | 6010/37798 (15.90) | 25.06 (24.30–25.85) |
| Stratified by primary disease | |||
| Schizophrenia | 1060/27277 (3.89) | 1398/4160 (33.61) | 12.52 (11.45–13.68) |
| Bipolar disorder | 649/23332 (2.78) | 2459/10676 (23.03) | 10.46 (9.56–11.45) |
| Stratified by drug combination | |||
| Haloperidol | 308/12393 (2.49) | 1219/2712 (44.95) | 32.04 (27.96–36.71) |
| Lithium | 351/13116 (2.68) | 785/3771 (20.82) | 9.56 (8.38–10.91) |