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. 2015 Dec 21;78(4):649–656. doi: 10.1292/jvms.15-0625

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©2016 The Japanese Society of Veterinary Science

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Fig. 4. — MEK2 immunohistochemical staining (× 400). (A) Hemangiosarcoma (HSA) showing weak (1+) cytoplasmic and nuclear expression (arrowheads) in Case 5. (B) HSA showing strong (2+) cytoplasmic and nuclear expression (arrowheads) in Case 2. (C) HSA showing strong (3+) cytoplasmic and nuclear expression (arrowheads) in Case 8. (D) A normal spleen showing no expression (control), which may reflect the presence of weak MEK2-expressing endothelial cells (arrowheads) and macrophages (arrow), in Case 12. Bar, 60 µm.