Table 1. Type of interaction between doxorubicin and deracoxib in CMT-U27 cells.
Combination of DOX with DER | RI value |
---|---|
DOX (0.9 µM) | |
DOX+ DER (50 µM) | 2.24 (synergistic) |
DOX+ DER (100 µM) | 1.98 (synergistic) |
DOX+ DER (250 µM) | 2.33 (synergistic) |
DOX (0.09 µM) | |
DOX+ DER (50 µM) | 1.15 (additive) |
DOX+ DER (100 µM) | 1.13 (additive) |
DOX+ DER (250 µM) | 1.08 (additive) |
DOX, doxorubicin; DER, deracoxib; RI, ratio index. Type of interaction: RI≥1.5, synergistic; RI<1.5 to >0.5, additive; RI≤0.5, antagonistic interaction.