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. 2016 May 20;16:117. doi: 10.1186/s12884-016-0902-3

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© Brownfoot et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Effects of statins on sFlt-1 secretion and mRNA expression of isoforms e15a and i13 expression in primary HUVECs. a Simvastatin (0, 1, 2, 5 μM) rosuvastatin (0, 1, 2, 5 μM) and pravastatin (0, 2, 5, 200 μM) reduce sFlt-1 secretion from primary HUVECs. b Inhibitory concentration of sFlt-1 at 50 % (IC50) for simvastatin, rosuvastatin and pravastatin was determined. c Pravastatin, simvastatin and rosuvastatin reduce sFlt-1 e15a mRNA expression from primary HUVECs. d Simvastatin reduces sFlt-1 i13 mRNA expression from HUVECs whilst pravastatin and rosuvastatin have no effect. Data represents n = 3 separate experiments and is expressed as mean ± SEM. Dark blue bars = control, light blue bars = statin treatments. b = p < 0.01, d = p < 0.0001