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. 2016 May 20;16:117. doi: 10.1186/s12884-016-0902-3

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© Brownfoot et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Effect of statins on heme-oxygenase 1 mRNA expression. a Simvastatin (0, 5 μM), rosuvastatin (0, 5 μM) and Pravastatin (0, 200 μM) up-regulated heme-oxygenase 1 expression by HUVECs. b Simvastatin 100 μM up-regulated heme-oxygenase 1 in preeclamptic placental explants, whist pravastatin 2000 μM and rosuvastatin 100 μM had no significant effect. Data represents n = 3–4 separate experiments and is expressed as mean ± SEM. Dark blue bars = control, light blue bars = statin treatments. a = p < 0.05, c = p < 0.001, d = p < 0.0001