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. 2016 May 19;7:11649. doi: 10.1038/ncomms11649

Figure 2. Hypertonic saline enhancement of ss-InFroM formation.

Figure 2

(a) Cyclosporine A (CsA) ss-InFroM yield formed at varying salt concentrations. (b) Lower washing temperatures enable surfactant stripping in hypertonic saline. (c) Molar ratio of drug to solubilizing excipient for CsA. (d) Immunosuppresion induced by CsA ss-InFroMs, based on IgM response to intraperitoneal injection of sheep red blood cells. (e) Hypertonic saline effect on the loading of testosterone undecanoate (T-undec) in F127 micelles. (f) Molar ratio of drug to solubilizing excipient for T-undec. Values show mean ±s.d. for n=3, or n=4–5 for animal studies. (g) Fluorescence images of extracted organs following intravenous injection of T-undec co-loaded with 2% BPc in ss-InFroMs or castor oil. Representative of 3 independent experiments. (h) Testosterone levels in castrated mice before and 1 week following subcutaneous injection of indicated T-undec doses in ss-InFroM form. Testosterone (T.) levels were assessed by ELISA specific for active testosterone (n=3 mice per group).