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. 2016 May 19;7:11649. doi: 10.1038/ncomms11649

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(a) Hypertonic saline enhanced the yield of cabazitaxel (CTX) InFroMs. (b) Coenzyme Q10 (CoQ) co-loading improved CTX InFroM stability following dilution into water. (c) Molar ratio of drug to solubilizing excipient for CTX formulations. (d) Haemolysis of human erythrocytes induced by CTX formulations. (e) Complement activation in human plasma induced by CTX formulations. (f) Time needed for mouse weight recovery after two injections of 30 mg kg⁻¹ CTX on days 0 and 4. Mice recovered significantly faster with ss-InFroMs (Student's unpaired T-test, P<0.05) (g) Anti-tumour efficacy of CTX ss-InFroMs intravenously injected in nude mice bearing subcutaneous MIA Paca-2 tumours. Two injections were given with the indicated doses on days 0 and 4 (indicated by arrows). Values show mean±s.d. for n=3; or n=5–6 for animal studies; or n=4 for blood tests.