Table 1.

Structures of isatin sulfonamide analogs as caspase-3 inhibitors

Compound	n	R	R′	IC50 (nM)	EC50 (μM)*
WC-II-89	2			9.70 ± 1.28	4.50 ± 1.10
WC-4-35	2			13.7 ± 1.0	1.30 ± 0.25
WC-4-36	1			26.9 ± 4.4	0.6 ± 0.08*
WC-4-116	2			4.5 ± 0.7	0.35 ± 0.04
WC-4-122	1			5.6 ± 0.5	0.42 ± 0.10
ICMT-11†	2			10.8 ± 0.4	0.68 ± 0.20
WC-4-131	1			13.4 ± 2.0	1.06 ± 0.20

^*Measured in HeLa cells treated with staurosporine; all published in ref 4 except for WC-4-36

^†Structure previously reported in ref 20

IC₅₀ = Half maximal inhibitory concentration

EC₅₀ = Half maximal effective concentration