. Author manuscript; available in PMC: 2016 Jun 1.

Published in final edited form as: Mol Imaging Biol. 2015 Jun;17(3):384–393. doi: 10.1007/s11307-014-0802-8

Table 2.

Metabolism of representative 2^nd and 3^rd generation isatin sulfonamides

Compound	Organ	5 min		30 min
Compound	Organ	% parent	% extraction	% parent	% extraction
[¹⁸F]WC-4-116^*	Blood	60 ± 10	80 ± 3	23 ± 9	60 ± 23
[¹⁸F]WC-4-116^*	Liver	32 ± 6	75 ± 5	16 ± 2	66 ± 5
[¹⁸F]WC-4-35^**	Blood	93 ± 5	94 ± 0.8	78 ± 12	94 ± 0.8
[¹⁸F]WC-4-35^**	Liver	56 ± 6	71 ± 11	39 ± 7	67 ± 5

% parent = percent of parent measured by thin-layer chromatography (TLC)

% extraction = percent of counts recovered from either plasma or liver for TLC analysis

N=6 animals, three separate experiments

^**

N=4 animals, two separate experiments